Quantification of HDL Particle Concentration by Calibrated Ion Mobility Analysis
نویسندگان
چکیده
منابع مشابه
Quantification of HDL particle concentration by calibrated ion mobility analysis.
BACKGROUND It is critical to develop new metrics to determine whether HDL is cardioprotective in humans. One promising approach is HDL particle concentration (HDL-P), the size and concentration of HDL in plasma. However, the 2 methods currently used to determine HDL-P yield concentrations that differ >5-fold. We therefore developed and validated an improved approach to quantify HDL-P, termed ca...
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We read with interest the report by Caulfield et al. (1 ) describing a new method for measuring lipoprotein particle concentrations by ion mobility (IM) analysis. There is growing evidence that the LDL particle concentration, as assessed by apolipoprotein B (apo B) or nuclear magnetic resonance (NMR) measurements, is a better discriminator of cardiovascular risk than the LDL cholesterol concent...
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BACKGROUND Current methods for measuring the concentrations of lipoprotein particles and their distributions in particle subpopulations are not standardized. We describe here and validate a new gas-phase differential electrophoretic macromolecular mobility-based method (ion mobility, or IM) for direct quantification of lipoprotein particles, from small, dense HDL to large, buoyant, very-low-den...
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Although nonnative protein conformations, including intermediates along the folding pathway and kinetically trapped misfolded species that disfavor the native state, are rarely isolated in the solution phase, they are often stable in the gas phase, where macromolecular ions from electrospray ionization can exist in varying charge states. Differences in the structures of nonnative conformations ...
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Background: The ion mobility spectrometry (IMS) is an analytical technique that is widely used due to its high sensitivity and speed for the detection of ionized molecules in gas phase and under atmospheric pressure. Breath analysis is a new method for obtaining information about person's clinical conditions that is considered by researchers. Human exhaled air contains a variety of components s...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2014
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2014.228114